Otezla (Apremilast): A Comprehensive Guide to Uses, Dosage, Side Effects

Otezla, known generically as apremilast, is an oral medication prescribed for certain inflammatory conditions. This guide provides an overview of Otezla’s uses, dosing guidelines, potential side effects, and strategies to manage its cost, including resources like GoodRx.GoodRx

What Is Otezla?

Otezla is a phosphodiesterase 4 (PDE4) inhibitor that works by reducing inflammation through modulation of intracellular signaling pathways. It’s FDA-approved for the treatment of:

Plaque Psoriasis: Moderate to severe cases in adults.
Psoriatic Arthritis: Active cases in adults.
Behçet’s Disease: Specifically for oral ulcers in adults.GoodRx+5GoodRx+5GoodRx+5 GoodRx+8GoodRx+8GoodRx+8 GoodRx+5GoodRx+5GoodRx+5

Unlike biologic therapies that require injections, Otezla is administered orally, offering a convenient option for many patients.GoodRx+1GoodRx+1

Dosage and Administration

Otezla is typically initiated with a titration schedule to minimize gastrointestinal side effects:GoodRx+1GoodRx+1

Day 1: 10 mg in the morning.
Day 2: 10 mg in the morning and evening.
Day 3: 10 mg in the morning and 20 mg in the evening.
Day 4: 20 mg in the morning and evening.
Day 5: 20 mg in the morning and 30 mg in the evening.
Day 6 and thereafter: 30 mg twice daily.GoodRx

For patients with severe renal impairment, the recommended dose is 30 mg once daily. GoodRx+1GoodRx+1

Potential Side Effects

Common side effects include:

Gastrointestinal Issues: Diarrhea, nausea, and vomiting, particularly during the initial weeks of treatment.
Headache.
Upper respiratory tract infections.
Weight loss.GoodRx

Otezla may also increase the risk of depression. Patients should inform their healthcare provider of any history of depression or suicidal thoughts. GoodRx+1GoodRx+1

Cost Considerations and Savings

Otezla can be expensive, with a 30-day supply costing around $5,000 without insurance. GoodRx

Savings Options:

GoodRx Coupons: GoodRx offers coupons that can significantly reduce the out-of-pocket cost of Otezla.
Manufacturer Co-Pay Program: Eligible patients with commercial insurance may pay as little as $0 per month.
Patient Assistance Programs: Programs like those from the PAN Foundation can provide financial assistance to eligible patients. GoodRx+3GoodRx+3GoodRx+3 GoodRx

Comparisons with Other Treatments

When compared to biologic therapies like Humira:

Administration: Otezla is oral; Humira is injectable.
Side Effects: Otezla commonly causes gastrointestinal issues; Humira may increase the risk of serious infections.
Cost: Both are expensive, but savings programs are available for each.GoodRx

Patients should consult with their healthcare provider to determine the most appropriate treatment option.

Conclusion

Otezla offers a convenient oral treatment option for certain inflammatory conditions. While it can be costly, resources like GoodRx and manufacturer assistance programs can help manage expenses. Patients should work closely with their healthcare providers to monitor for side effects and assess the effectiveness of the therapy.

May 26, 2025