Medically Reviewed by AJAY AWASE | Written by Ajay, PharmD, IGNTU

Overview

Certain plants, including tree turmeric, phellodendron, goldenseal, goldthread, European barberry, and Oregon grape, contain a substance called berberine.

Berberine is a chemical with a yellow hue and an unpleasant taste. For those with specific heart disorders, it may assist strengthen the heartbeat. In addition, it may assist control how the body uses blood sugar, eradicate microorganisms, and lessen edema. Pill Recognizer

Berberine is most frequently used by people to treat high blood pressure, excessive cholesterol, or other fat levels in the blood. In addition, it is used to treat liver illness, burns, canker sores, and a host of other ailments; however, not all of these applications have strong scientific backing. Pill Recognizer

Uses of Berberine

• Diabetes: Berberine has been shown to lower blood sugar levels and improve insulin sensitivity, making it a potential treatment for type 2 diabetes.
• Cholesterol: Berberine may help reduce “bad” LDL cholesterol and triglyceride levels while increasing “good” HDL cholesterol.
• Digestive health: Berberine has been used to treat diarrhea, constipation, and irritable bowel syndrome (IBS). Pill Recognizer
• Antioxidant properties: Berberine has antioxidant properties that may help protect cells from damage.
• Anti-inflammatory effects: Berberine may have anti-inflammatory properties that can help reduce inflammation in the body. Pill Recognizer

Side Effects of Berberine

Drug interactions: Berberine may interact with certain medications, so it is important to talk to your doctor before taking it if you are on any other medications.

Digestive problems: Some people may experience digestive problems, such as diarrhea, constipation, or nausea. Pill Recognizer

Low blood pressure: Berberine may lower blood pressure, so it is important to monitor your blood pressure if you are taking it.

Berberine Precautions and Warnings

Berberine, while generally considered safe, does come with certain precautions and warnings:

• Pregnancy and Breastfeeding: If you are pregnant or breastfeeding, consult with your healthcare provider before taking berberine. While limited research suggests it may be safe, more studies are needed to fully understand its effects during these periods.
• Medication Interactions: Berberine may interact with certain medications, potentially affecting their efficacy or causing adverse side effects. Inform your doctor about all medications you are taking, including over-the-counter drugs, herbal supplements, and prescription medications. Pill Recognizer
• Blood Pressure: Berberine can lower blood pressure. If you have low blood pressure or are taking medications to manage it, monitor your blood pressure closely while using berberine.
• Digestive Issues: Berberine can sometimes cause digestive side effects like diarrhea or constipation. If you have existing digestive problems, consult your doctor before taking berberine.
• Allergic Reactions: While rare, allergic reactions to berberine are possible. If you experience symptoms like hives, swelling, or difficulty breathing after taking berberine, seek immediate medical attention. Pill Recognizer
• Dosage: It’s crucial to follow the recommended dosage of berberine. Excessive intake can lead to side effects. Pill Recognizer

Berberine can interact

with certain medications, potentially affecting their efficacy or causing adverse side effects. Here are some notable interactions:

Blood Thinners: Berberine may enhance the blood-thinning effects of anticoagulant medications like warfarin or aspirin. This can increase the risk of bleeding. If you are taking blood thinners, consult your doctor before starting berberine. Pill Recognizer

Diabetes Medications: Berberine can lower blood sugar levels. If you are taking diabetes medications, your doctor may need to adjust your dosage to prevent hypoglycemia (low blood sugar).

Antibiotics: Some antibiotics, such as erythromycin and clarithromycin, may interfere with the absorption of berberine. It’s recommended to take these medications at least 2 hours apart.

Digestive Enzymes: Berberine may interact with digestive enzymes used to treat pancreatic insufficiency. Consult your doctor for guidance on how to take these medications together. Pill Recognizer

Iron Supplements: Berberine may reduce the absorption of iron from iron supplements. If you are taking iron supplements, consider taking them at a different time of day than berberine. Pill Recognizer

Other Medications: It’s essential to inform your doctor about all medications you are taking, including over-the-counter drugs, herbal supplements, and prescription medications, to assess potential interactions with berberine. Pill Recognizer

FAQ:

1. What foods are high in berberine?

As previously indicated, berberine is extracted from the roots, stems, and bark of plants like barberry, Chinese goldthread, goldenseal, tree turmeric, and Oregon grape. It is not present in any common dietary sources. Pill Recognizer